A deltaic—lagoonal depositional system has been identified in the Triassic of the Bergamasc Alps (Lombardy, northern Italy). The following sedimentary environments have been distinguished:
A) subaerial delta Plain (reddish sandstones and siltstones organized in fining—upward sequences); B) Iower delta Plain / delta front / proximal prodelta (greenish sandstones and siltstones, locally organized in fining—upward sequences) ;
BI) near—shore lagoonal areas situated far from the "entry—points" of the sands (alternating dark grey limestones — often oolitic grainstones and dark grey mudrocks, with some greenish sandstones and grey hybrid arenites
C) distal prodelta (alternating dark grey mudrocks, dark grey limestones and greenish sandstones); D) central part of the lagoon (dark grey limestones and marls; locally dark grey mudrocks).
Plant-based diets (PBDs) are increasingly consumed by the Italian population and around the world. In particular, among PBDs, the vegan diet is a food pattern characterized by the exclusion of all animal-origin foods. What drives people to adopt this model are mainly ethical, health and environmental reasons. A vegan diet, if well-balanced and varied, can help in achieving and maintaining an optimal state of health. However, this nutritional approach, if not well-balanced, can cause deficiencies in proteins, ω-3 fatty acids, iron, vitamin D and calcium, zinc, iodine and, above all, vitamin B12. Oral food supplements especially fortified foods are recommended in these cases to restore the nutritional deficiencies. A vegan diet generally reduces the risk of developing chronic non-communicable degenerative diseases, such as metabolic syndrome (MetS) and, in addition, requires fewer natural resources for food production than an omnivorous diet. The aim of this review is to analyze the possible impact of the vegan diet on MetS onset and its treatment.
In Anna Seghers’ short story, Gita delle ragazze morte (1943-1944) and in Claudio Magris’ Esterno giorno – Val Rosandra (1982), a group of high school friends and their trip on the eve of World War I provide the narrative nucleus around which individual micro-histories meet macro-history. In the proposed analysis, the reason for the deprivation is identified as an element common to the two texts. In Seghers’ story, the temporal distance is cancelled out in a continuum, whereas Magris’ story operates through multiplication and fading between different typologies of texts: novel, screenplay, film, Goethe’s Faust, and short story.
Uremic sarcopenia is a frequent condition present in chronic kidney disease (CKD) patients and is characterized by reduced muscle mass, muscle strength and physical performance. Uremic sarcopenia is related to an increased risk of hospitalization and all-causes mortality. This pathological condition is caused not only by advanced age but also by others factors typical of CKD patients such as metabolic acidosis, hemodialysis therapy, low-grade inflammatory status and inadequate protein-energy intake. Currently, treatments available to ameliorate uremic sarcopenia include nutritional therapy (oral nutritional supplement, inter/intradialytic parenteral nutrition, enteral nutrition, high protein and fiber diet and percutaneous endoscopic gastrectomy) and a personalized program of physical activity. The aim of this review is to analyze the possible benefits induced by nutritional therapy alone or in combination with a personalized program of physical activity, on onset and/or progression of uremic sarcopenia.
Annalisa Noce, Manuela Di Lauro, Francesca Di Daniele
Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.
Nicola Di Daniele, Giulia Marrone, Manuela Di Lauro
The most common manifestation of cardiovascular (CV) diseases is the presence of arterial hypertension (AH), which impacts on endothelial dysfunction. CV risk is associated with high values of systolic and diastolic blood pressure and depends on the presence of risk factors, both modifiable and not modifiable, such as overweight, obesity, physical exercise, smoking, age, family history, and gender. The main target organs affected by AH are the heart, brain, vessels, kidneys, and eye retina. AH onset can be counteracted or delayed by adopting a proper diet, characterized by a low saturated fat and sodium intake, a high fruit and vegetable intake, a moderate alcohol consumption, and achieving and maintaining over time the ideal body weight. In this review, we analyzed how a new nutritional approach, named caloric restriction diet (CRD), can provide a significant reduction in blood pressure values and an improvement of the endothelial dysfunction. In fact, CRD is able to counteract aging and delay the onset of CV and neurodegenerative diseases through the reduction of body fat mass, systolic and diastolic values, free radicals production, and oxidative stress. Currently, there are few studies on CRD effects in the long term, and it would be advisable to perform observational studies with longer follow-up.
Elisabetta Di Bello, Beatrice Noce, Rossella Fioravanti
Epigenetic modifications in eukaryotic biological pathways can lead to the up- or downregulation of regulatory proteins contributing to disease onset and progression. In the last three decades, histone deacetylases (HDACs) are among the most studied epigenetic targets. In fact, aberrant HDAC expression is associated with numerous types of cancer and neurodegenerative disorders, making HDACs promising molecular targets for the design of new drugs. Many HDAC inhibitors (HDACi) are currently in clinical evaluation for various types of cancer, and some of them reached the market after approval by the Food and Drug Administration (FDA). The present review summarizes the various HDAC classes and relative isoforms. Then we discuss different class or isoform-selective HDACi with a strong emphasis on late-stage preclinical candidates and drugs in clinical studies. Last but not least, we shed light on the pharmacokinetic challenges and future directions in HDACi design.
AbstractWe study the portraits of isometries of rooted trees—the labelling of the tree, at each vertex, by the permutation of its descendants—in terms of languages. We characterize regularly branched self-similar groups in terms of $$\omega $$
ω
-regular languages. We deduce the algorithmic decidability of some problems, such as the comparison of regularly branched contracting groups, and their orbit structure on the boundary of the rooted tree.
Il presente contributo affronta il tema della letteratura odeporica come fonte per l’ecologia storica e per la storia dei paesaggi boschivi. Raccogliendo le riflessioni offerte in questo campo da Oliver Rackham e Emilio Sereni, si sperimentano le potenzialità e le criticità euristiche di un corpus di opere di viaggio in un caso studio localizzato nelle Alpi trentine. La costruzione di un Historical GIS consente di sistematizzare, localizzare e consultare spazialmente le fonti. I primi paragrafi presentano gli studi di riferimento nel campo della geografia storica e dei GIS; il terzo paragrafo illustra il caso studio; il quarto paragrafo presenta il metodo utilizzato. Successivamente, il corpus è analizzato riguardo a tre tematiche centrali, ovvero gli itinerari di viaggiatori e viaggiatrici, la storia della copertura del suolo e le pratiche rurali del passato. In conclusione, il saggio permette di verificare l’efficacia della fonte per studi di geografia storica del bosco, e suggerisce l’uso dello strumento GIS per una lettura sistematica di ampi dataset per superare alcune criticità presentate dalla bibliografia.
Aldair Baia Farias, Luisa Margareth Carneiro da Silva, Rosilene Reis Della Noce
Objetivo: Avaliar, por meio de revisão integrativa da literatura, a eficácia da dieta cetogênica clássica (DCC) na redução das crises epilépticas em crianças com epilepsia refratária e seu impacto na qualidade de vida. Métodos: Trata-se de uma revisão integrativa da literatura. Foram consultadas as bases de dados BVS, PubMed, Scielo e Periódicos CAPES, e foram utilizados os descritores “epilepsia refratária”, “dieta cetogênica” e “crianças”. Incluíram-se artigos publicados entre 2020 e 2025, nos idiomas portugues, inglês e espanhol, que abordassem a aplicação da DCC em crianças com epilepsia refratária. Excluíram-se estudos com adultos, relatos isolados e publicações sem texto completo disponível Resultados: Foram incluídos quinze estudos na amostra final. Os estudos evidenciaram redução igual ou superior a 50% na frequência das crises epilépticas, sendo que alguns trabalhos reportaram eficácia de até 85% e ocorrência de casos de remissão completa. Os efeitos adversos mais frequentemente descritos compreenderam constipação intestinal e episódios de hipoglicemia, predominando nas fases iniciais da intervenção dietética. Considerações finais: DDC configurou-se como uma abordagem eficaz e segura para o controle da epilepsia refratária em crianças, demonstrando benefícios clínicos significativos.
Chronic kidney disease (CKD) represents a major global health challenge due to its high prevalence in the general population and its substantial impact in terms of morbidity, mortality, and healthcare costs [...]
Proponse o estudio do interese social do aproveitamento da biomasa forestal para as comunidades de montes do Val Miñor, e a xestión dese proceso directamente pola comunidade de montes.
CORE.ac.uk (akademski agregator)🇬🇧 Velika Britanija (CORE)2014-01-01T00:00:00📍 valdanosacademicit
D'Onghia, Luca
Sulla base di un ampio spoglio l\u2019articolo esamina dal punto di vista linguistico le lettere e i Ricordi di Michelangelo, con particolare attenzione alla fonetica e alla sintassi. Ne risulta la natura prevalentemente funzionale e non letteraria della scrittura michelangiolesca, e vengono fatte alcune osservazioni su aspetti storici e culturali dei Ricordi
CORE.ac.uk (akademski agregator)🇬🇧 Velika Britanija (CORE)2007-01-01T00:00:00📍 valdanosacademic
Ediert werden zwei im Jahr 2001 vom Herausgeber wiedergefundene Rechnungsbücher zu Bau- und Ausstattungsgeschichte der Cappella Bernabò in S. Giovanni Crisostomo zu Venedig. Ergänzt werden die beiden Dokumente um mehrere Register, einen Glossar und einen tabellarischen Anhang, der vor allem die finanziellen Transaktionen und Aspekte dieser Quellen erläutert. Die beiden Rechnungsbücher oder quaderni zur Kapelle bieten auf weiten Strecken die einzigen Zeugnisse für den Neubau der Kirche von S. Giovanni Crisostomo in den Jahren um 1500. Im größeren Kontext Venedigs und der Wende zum 16. Jahrhundert gesehen, bieten sie eine außergewöhnlich vollständige Dokumentation zu einem einzelnen Bauprojekt, zu den finanziellen Vorgehensweisen der verantwortlichen fabbrica und zur Struktur des ausführenden cantiere
CORE.ac.uk (akademski agregator)🇬🇧 Velika Britanija (CORE)2025-04-15T01:00:00📍 valdanosacademicit
Gallo, Annarosa
EnThe ager publicus populi Romani in Hirpinia was established after the Hannibal's war, as a punishment of the rebel communities. Lands were distributed among veterans of Scipio, Gracchan assignees, veterans of Sulla and beneficiaries of the lex Iulia agraria (59 BC.). The praefecti of the praetor urbanus administered the justice for them. Around mid- I century BC., the land assignees located in the upper valley of the Calore and of the Ofanto were confered to Compsa, while those in the valley of the Ansanto were organized into an autonomous local community whose identity is still unknown.DeIn Hirpinia wurde der ager publicus populi Romani nach dem hannibalischen Krieg als Bestrafung für die aufständischen Gemeinden gegründet. Hauptsächlich diente er, in verschiedenen Zeiten, der Ansiedlung der Veteranen von Scipios, Ti. Gracchus, Sullas, sowie von Begünstigten nach der lex Iulia agraria (59 v. Chr.). Zugunsten dieser Assignataren beauftragte der Prätor einen oder mehrere Präfekten zur Ausübung der Rechtspflege. Um die Hälfte des 1. Jahrhunderts v. Ch. wurden die Assignataren im oberen Tal des Calore und des Ofanto zu dem municipium von Compsa zugeschrieben. Die Assignataren im Tal des Ansanto wurden dagegen zum Rang eines municipium erh oben. Die Identität dieses municipium bleibt noch unbekannt