Arhiva Ulcinj

Xosé Manuel Dasilva

Se trata de una recensión del volumen Autotraduzione. Pratiche, teorie, storie / Autotraduction. Pratiques, théories, histoires, cuyo coordinador es Fabio Reggattini, publicado recientemente. En él se explora el hecho autotraductor combinando reflexiones de personas que suelen verterse a sí mismas y estudios realizados por especilialistas en esta particular modalidad de traducción.

Roberto Bosi

To trace back the history of the Berlin Castle from its foundation to the present day is like making an incursion into the political and urban history of the city it represents, in which the act of reconstruction becomes the moment of re-appropriation, on the one hand, of the ‘evocative efficacy’ of the Castle and, on the other, of the rediscovery of the special relationship that once connected the monument to the city and was later lost. The urban mission of the work and the fact of its being a monument lie at the centre of Franco Stella’s project.

Riccardo Serraglio

In 1954 the architects Roberto Pane and Ezio De Felice were commissioned by the Caserta Provincial Tourist Board to draw up the restoration project of the medieval village of Casertavecchia. After some modifications were made, in 1961 the project was financed by the Cassa per il Mezzogiorno. The plan was not limited to the restoration of the architectural emergencies, such as the cathedral of San Michele Arcangelo, but it involved the recovery of the medieval building fabric and the disused castle. Unfortunately, the intervention was only partially achieved due to lack of economic resources and so it has been deprived of its organicity. At the time of the plan of Pane and De Felice, the castle was not restored because it was covered with vegetation and debris. Only from the mid-1980s to the present day, many structures of the castle have been restored but still a destination has not been established for the covered hall and for the external areas of the building. Taken together, the urban renewal of the medieval village and the architectural restoration of the castle cannot be considered satisfactory and it is hoped that in the near future new interventions will be carried out with a scientific method.

Simona Inserra

Christiane M. A. De Micheli Schulthess

Giulia Marrone, Cristina Guerriero, Daniela Palazzetti

Plant-based diets (PBDs) are increasingly consumed by the Italian population and around the world. In particular, among PBDs, the vegan diet is a food pattern characterized by the exclusion of all animal-origin foods. What drives people to adopt this model are mainly ethical, health and environmental reasons. A vegan diet, if well-balanced and varied, can help in achieving and maintaining an optimal state of health. However, this nutritional approach, if not well-balanced, can cause deficiencies in proteins, ω-3 fatty acids, iron, vitamin D and calcium, zinc, iodine and, above all, vitamin B12. Oral food supplements especially fortified foods are recommended in these cases to restore the nutritional deficiencies. A vegan diet generally reduces the risk of developing chronic non-communicable degenerative diseases, such as metabolic syndrome (MetS) and, in addition, requires fewer natural resources for food production than an omnivorous diet. The aim of this review is to analyze the possible impact of the vegan diet on MetS onset and its treatment.

Rita Svandrlik

In Anna Seghers’ short story, Gita delle ragazze morte (1943-1944) and in Claudio Magris’ Esterno giorno – Val Rosandra (1982), a group of high school friends and their trip on the eve of World War I provide the narrative nucleus around which individual micro-histories meet macro-history. In the proposed analysis, the reason for the deprivation is identified as an element common to the two texts. In Seghers’ story, the temporal distance is cancelled out in a continuum, whereas Magris’ story operates through multiplication and fading between different typologies of texts: novel, screenplay, film, Goethe’s Faust, and short story.

Annalisa Noce, Giulia Marrone, Eleonora Ottaviani

Uremic sarcopenia is a frequent condition present in chronic kidney disease (CKD) patients and is characterized by reduced muscle mass, muscle strength and physical performance. Uremic sarcopenia is related to an increased risk of hospitalization and all-causes mortality. This pathological condition is caused not only by advanced age but also by others factors typical of CKD patients such as metabolic acidosis, hemodialysis therapy, low-grade inflammatory status and inadequate protein-energy intake. Currently, treatments available to ameliorate uremic sarcopenia include nutritional therapy (oral nutritional supplement, inter/intradialytic parenteral nutrition, enteral nutrition, high protein and fiber diet and percutaneous endoscopic gastrectomy) and a personalized program of physical activity. The aim of this review is to analyze the possible benefits induced by nutritional therapy alone or in combination with a personalized program of physical activity, on onset and/or progression of uremic sarcopenia.

, Paolo Armellini,

Annalisa Noce, Manuela Di Lauro, Francesca Di Daniele

Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.

Nicola Di Daniele, Giulia Marrone, Manuela Di Lauro

The most common manifestation of cardiovascular (CV) diseases is the presence of arterial hypertension (AH), which impacts on endothelial dysfunction. CV risk is associated with high values of systolic and diastolic blood pressure and depends on the presence of risk factors, both modifiable and not modifiable, such as overweight, obesity, physical exercise, smoking, age, family history, and gender. The main target organs affected by AH are the heart, brain, vessels, kidneys, and eye retina. AH onset can be counteracted or delayed by adopting a proper diet, characterized by a low saturated fat and sodium intake, a high fruit and vegetable intake, a moderate alcohol consumption, and achieving and maintaining over time the ideal body weight. In this review, we analyzed how a new nutritional approach, named caloric restriction diet (CRD), can provide a significant reduction in blood pressure values and an improvement of the endothelial dysfunction. In fact, CRD is able to counteract aging and delay the onset of CV and neurodegenerative diseases through the reduction of body fat mass, systolic and diastolic values, free radicals production, and oxidative stress. Currently, there are few studies on CRD effects in the long term, and it would be advisable to perform observational studies with longer follow-up.

Giuseppe Di Gregorio

Angelo Pitrone

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Augusto Del Noce

Elisabetta Di Bello, Beatrice Noce, Rossella Fioravanti

Epigenetic modifications in eukaryotic biological pathways can lead to the up- or downregulation of regulatory proteins contributing to disease onset and progression. In the last three decades, histone deacetylases (HDACs) are among the most studied epigenetic targets. In fact, aberrant HDAC expression is associated with numerous types of cancer and neurodegenerative disorders, making HDACs promising molecular targets for the design of new drugs. Many HDAC inhibitors (HDACi) are currently in clinical evaluation for various types of cancer, and some of them reached the market after approval by the Food and Drug Administration (FDA). The present review summarizes the various HDAC classes and relative isoforms. Then we discuss different class or isoform-selective HDACi with a strong emphasis on late-stage preclinical candidates and drugs in clinical studies. Last but not least, we shed light on the pharmacokinetic challenges and future directions in HDACi design.

Maria Júlia Silva Sverzut, Ana Carolina Montsutsumi Santos, Mariana Araújo Noce

Fabio Ambrogio

Giuseppe Mollo, Giuseppe Piccolo

Maria Pia Testa, Raffaele Catuogno, Andrea Pane

Maria Teresa Campisi

Mattia Francesco Antonio Cantatore

Le château de Canossa a fait l’objet de recherches archéologiques de 1877 à nos jours. En raison du manque de données actualisées concernant les pièces trouvées sur le site, nous partons de l’étude du matériel numismatique provenant des campagnes de fouilles menées en 2009 sur la place forte et en 2017-2018 dans la zone du bourg pour proposer également une étude critique des pièces découvertes lors des investigations du XIXe siècle. Ces dernières ont malheureusement été volées en 1921, mais il en reste une description partielle. Enfin, nous examinons une intéressante enseigne de pèlerinage romaine du XIIIe / XIVe siècle représentant saint Pierre et saint Paul, trouvée en 2018 dans le bourg.

Claudia Aveta

Carlos Alberto Cacciavillani

Giovanna Muscatello, Carmine Mitello

Laura Ribotta